<p><strong><em>Introduction </em></strong><em>Various natural medicinal compounds from traditional ingredients increasingly show an important role as another option for treatment. The use of antibiotics that are not appropriate will cause resistance to bacteria. Necessary natural remedies that have the same efficacy with antibiotics and smaller side effects. Wuluh star fruitleaf contain flavonoids, tannins, saponins and alkaloids which act as antibacterial. This study aims to determine the effectiveness of wuluh star fruitleaf extract on the growth of Escherichia coli bacteria.<strong>Method : </strong>The research method was carried out by laboratory experiments with samples of Escherichia coli bacteria. The extraction of wuluh starfruit leaf using maceration method with the concentration of wuluh starfruit leaf 10%, 20%, 30%, 40% and 50%. As a positive control using chloramphenicol antibiotics, negative control using sterile aquadest. Analyze data by coding and tabulating. Antibacterial testing was carried out using the disk diffusion method to determine the inhibition zone formed. <strong>Result : </strong>The results of this study indicate the formation of inhibition zones at each concentration of 10% is 6mm, 20% is</em></p>
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<p><em>8mm, 30% is 8.5mm, 40% is 9mm and 50% is 10mm. Chloramphenicol as an antibiotic shows inhibition of 25mm. <strong>Conclusion </strong>: Wuluh star fruitleaf extract is effective as an antimicrobial Escherichia coli bacteria with the greatest effectiveness at a concentration of 50%. People can use wuluh starfruit leaf as an alternative treatment for bacterial infections in Escherichiacoli. <strong>Suggestion </strong>: It is hoped that the community can use starfruit leaves (Avverhoa bilimbi L) as an alternative to natural antibiotics to treat Eschericia coli&nbsp; bacterial infections</em></p>
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<h2>Keywords: Antibiotic, Wuluh Star Fruit Leaf, Escherichia Coli.</h2>
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