<p><em>Chronic Kidney Disease (CKD) is a condition in which the kidneys cannot work normally. In the condition of chronic kidney disease, the decline in kidney function can occur slowly and chronically until the kidneys do not function at all. Hemodialysis is one of the therapies used to replaced kidney function. During hemodialysis, a decrease in hemoglobin levels often occurs, this is due to the disruption of the hormon erythropoietin. This research aims to determine the differences in hemoglobin levels in patients with chronic kidney disease before and after hemodialysis at </em>Bhayangkara TK. I Raden Said Sukanto<em> Hospital. <strong>Method: </strong>The design of this research&nbsp; is cross sectional using secondary data and the sampling technique of this research was random sampling with a total of 133 patients. <strong>Result: </strong>&nbsp;The normality test was carried out first using the Kolmogorov-Smirnov<sup>a </sup>test which showed the results were not normally distributed with a sig value of 0.001. the next test was the Wilcoxon test with a sig (2-tailed_ value of 0.002 with an average hemoglobin level of 8,81 g/dL before hemodialysis and 9,09 g/dL after hemodialysis. <strong>Conclusion:</strong></em><em> Based on the results of the study means that there is a significant difference in a patient with chronic kidney failure before and after hemodialysis.</em></p>
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