<p><em>The increasing number of positive Covid-19 cases has caused a surge in treatment room capacity so treating Covid-19 patients at home can be a consideration. This causes quite a few families who live together and care for family members who are exposed to COVID-19 to experience psychological distress. If the psychological distress experienced occurs over a long period and not managed well, it can affect both physical and psychological health. In dealing with the stress experienced, a person will do something which is called a coping mechanism. This study aims to determine the psychological distress response and coping mechanisms in families caring for COVID-19 patients at home. Article searches were carried out using five databases, namely Google Scholar, PubMed, Sciencedirect, EBSCO, and ProQuest with the inclusion criteria of psychological responses of families caring for Covid-19 patients, journals or articles that explain the coping mechanisms used by families in overcoming the psychological distress experienced, National and International free full-text articles or journals, qualitative studies, reviews, published in 2019-2022. Based on the identification results, 2,629 articles were obtained, then do the steps the screening, eligibility, and inclusion stages were carried out to obtain five articles. After that, the five articles were entered into the data extraction table and data mapping/scoping was carried out. Based on the results of data analysis that has been carried out, four main themes were obtained, namely negative psychological responses of families when caring for family members who are positive for Covid-19 at home, negative psychological symptoms of families when caring for family members who are positive for Covid-19 at home, cause the emergence of a family's negative psychological response when caring for a family member who is positive for Covid-19 at home, and the family's adaptive coping mechanisms (personal abilities, positive beliefs, social support, and spiritual support) in dealing with negative psychological responses. Based on the research results, it is hoped that families who care for family members suffering from COVID-19 at home will be able to increase their understanding of COVID-19 disease and how to properly care for patients by reading references from various valid or relevant sources.</em></p>