<p><strong><em>Introduction </em></strong><em>Typhoid fever is an acute infection caused by Salmonella typhi. This disease needs to be controlled by giving antibiotics. The use of antibiotics often causes resistance problems. The nature of bacterial resistance to these antibiotics, one of which is treated naturally by using honey. <strong>Objectives </strong>This study to determine the antibacterial activity of honey on strains Salmonella typhi. <strong>Methods </strong>This research was descriptive with cross sectional design. The samples were used pure bacterial culture of Salmonella typhi.&nbsp; Different concentrations (25 %, 50%, 75%, and Undiluted honey) and positive control using chloramphenicol. Each treatment was carried out 3 repetitions. Antibacterial testing using the paper disc diffusion method. <strong>Results </strong>Honey with concentrations of 25%, 50%, 75% and 100% inhibits the growth of Salmonella typhi with an average inhibition zone of 5 mm, 6,6 mm, 7,3 mm, and 8,3 mm. <strong>Conclusion </strong>Honey can inhibit growth Salmonella typhi with weak potential at a concentration of 25% and moderate potential at a concentration of 50-100%. <strong>Suggestion </strong>the next researcher conducted research with different types of microorganisms.</em></p>
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