<p>Hospital patient safety is a system where hospitals make patient care safer and prevent injuries caused by<br />faults due to carry out an action or not take action that should be taken. This could happen due to a lack of<br />knowledge of nurses about the concept of prevention of nosocomial infection. The purpose of this study was<br />to know the relationship of nurses’ knowledge with the effort of prevention of nosocomial infections at<br />inpatient unit Regional hospital Dr. Sayidiman Magetan.The study method used was Cross Sectional<br />Analytic. The researcher conducted measurement or research in one period. Population was as many as 59<br />nurses. Sample taken was all nurses as many as 59 people. Technique used in this study was total sampling<br />technique. Data collection of respondent used a questionnaire. Independent variable was nurse’s knowledge<br />about nosocomial infection and dependent variable was prevention effort of nosocomial infection. Data<br />processing used editing, coding, scoring, tabulating and correlational test of pearson.The study result of 59<br />respondents of nurse’s knowledge about prevention of nosocomial infection had correlation coefficient with<br />the prevention of nosocomial infection with a significant value of p-value = 0,025 &lt; 0,05 where the value of r<br />= 0,293, which means anyrelationship of nurse's knowledge with prevention of nosocomial infection. The<br />conclusion of this study, nurses with the knowledge of prevention of nosocomial infections in normal<br />distribution.</p><p><br />Keywords: Knowledge, Nurse,Nosocomial Infection</p>